Pt0.5?Snx/γ?Al2O3 catalysts with different Sn loads were prepared by constant volume sequential impregnation method and ultrasonic shock method to improve metal dispersion. The catalysts were characterized by XRD, BET, H2?TPR, CO?IR and TG, and the effects of Sn content on the active center structure and propane dehydrogenation performance of Pt0.5?Snx/γ?Al2O3 catalysts were investigated. The results showed that adjusting the n(Pt)/n(Sn) by changing the Sn content in the samples would lead to the difference in the spatial distribution of Pt and Sn species, and thus affect the mode of action between Pt and Sn. With the increase of Sn, the interaction between Pt?Sn helps to increase the dispersion of Pt, the number of active sites, the improvement of the reaction activity of the catalyst. However, when excessive Sn is introduced, a Pt?Sn alloy is formed, resulting in the coating of Pt, resulting in a decrease in the number of active sites and a decline in the reactivity.